Petr Starostik

Petr Starostik, M.D.

PRG DIR & CLIN PROF

Department: MD-PATHOLOGY-GENERAL
Business Phone: (352) 265-9900
Business Email: starostik@pathology.ufl.edu

Board Certifications

  • Clinical Pathology
    American Board of Pathology
  • Hematopathology
    American Board of Pathology
  • Molecular Genetic Pathology
    American Board of Pathology

Publications

2021
A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management.
Genetics in medicine : official journal of the American College of Medical Genetics. 23(4):621-628 [DOI] 10.1038/s41436-020-01050-4. [PMID] 33420349.
2021
Mixed acinar-neuroendocrine carcinoma with amphicrine features of the pancreas: Two rare cases with diffuse co-expression of acinar and neuroendocrine markers.
Pathology international. [DOI] 10.1111/pin.13105. [PMID] 34000758.
2021
Pathology Informatics and Robotics Strategies for Improving Efficiency of COVID-19 Pooled Testing.
Academic pathology. 8 [DOI] 10.1177/23742895211020485. [PMID] 34189259.
2021
The Hologic Aptima SARS-CoV-2 assay enables high ratio pooling saving reagents and improving turnaround time.
Journal of clinical laboratory analysis. [DOI] 10.1002/jcla.23888. [PMID] 34213803.
2020
Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(2):439-449 [DOI] 10.1158/1078-0432.CCR-19-1667. [PMID] 31548343.
2020
How to Transition from Single-Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.
Clinical pharmacology and therapeutics. 108(3):557-565 [DOI] 10.1002/cpt.1912. [PMID] 32460360.
2020
Malignant round cell tumor with SS18-POU5F1 fusion: is it a myoepithelial neoplasm, a synovial sarcoma or a new entity?
Histopathology. 77(4):681-684 [DOI] 10.1111/his.14171. [PMID] 32516451.
2020
Optimizing COVID-19 testing capabilities and clinical management using pathology informatics.
JAMIA open. 3(4):523-529 [DOI] 10.1093/jamiaopen/ooaa055. [PMID] 33754137.
2020
SMARCA4-Deficient Thoracic Sarcoma: A Case Report and Review of Literature.
International journal of surgical pathology. 28(1):102-108 [DOI] 10.1177/1066896919865944. [PMID] 31382829.
2019
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics. 21(8):1842-1850 [DOI] 10.1038/s41436-018-0431-8. [PMID] 30670877.
2019
Gastric Plexiform Fibromyxoma: A Great Mimic of Gastrointestinal Stromal Tumor (GIST) and Diagnostic Pitfalls.
The Journal of surgical research. 239:76-82 [DOI] 10.1016/j.jss.2019.01.062. [PMID] 30822694.
2019
Mapping the Mutation Landscape of Colorectal Cancer.
The American journal of the medical sciences. 358(5):313-314 [DOI] 10.1016/j.amjms.2019.08.004. [PMID] 31655711.
2018
Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention.
Journal of translational medicine. 16(1) [DOI] 10.1186/s12967-018-1469-8. [PMID] 29642909.
2018
Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.
Contemporary clinical trials. 68:7-13 [DOI] 10.1016/j.cct.2018.03.001. [PMID] 29535047.
2018
Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions. 11(2):181-191 [DOI] 10.1016/j.jcin.2017.07.022. [PMID] 29102571.
2018
Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.
Genetic testing and molecular biomarkers. 22(4):266-269 [DOI] 10.1089/gtmb.2017.0261. [PMID] 29641284.
2017
Clinical mutation assay of tumors: new developments.
Anti-cancer drugs. 28(1):1-10 [PMID] 27575332.
View on: PubMed
2017
Institutional profile: University of Florida Health Personalized Medicine Program.
Pharmacogenomics. 18(5):421-426 [DOI] 10.2217/pgs-2017-0028. [PMID] 28346068.
2016
Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML.
Case reports in hematology. 2016 [DOI] 10.1155/2016/1259759. [PMID] 28127477.
2015
Routine Clinical Mutation Profiling of Non-Small Cell Lung Cancer Using Next-Generation Sequencing.
Archives of pathology & laboratory medicine. 139(7):913-21 [DOI] 10.5858/arpa.2014-0095-OA. [PMID] 26125431.
2014
Deletion and deletion/insertion mutations in the juxtamembrane domain of the FLT3 gene in adult acute myeloid leukemia.
Leukemia research reports. 3(2):86-9 [DOI] 10.1016/j.lrr.2013.09.003. [PMID] 25379410.
2013
Development and characterization of a novel human Waldenström macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute – Waldenström Macroglobulinemia 1.
Leukemia & lymphoma. 54(2):387-96 [DOI] 10.3109/10428194.2012.713481. [PMID] 22812491.
2013
Phase II trial of clofarabine and daunorubicin as induction therapy for acute myeloid leukemia patients greater than or equal to 60 years of age.
Leukemia research. 37(11):1468-71 [DOI] 10.1016/j.leukres.2013.07.036. [PMID] 24011826.
2013
Primary intraplacental gestational choriocarcinoma: histologic and genetic analyses.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 32(1):71-5 [DOI] 10.1097/PGP.0b013e3182566552. [PMID] 23202784.
2012
Monoallelic and biallelic deletions of 13q14.3 in chronic lymphocytic leukemia: FISH vs miRNA RT-qPCR detection.
American journal of clinical pathology. 137(4):641-6 [DOI] 10.1309/AJCPP31FSSRQTTAQ. [PMID] 22431542.
2011
ERBB2 juxtamembrane domain (trastuzumab binding site) gene mutation is a rare event in invasive breast cancers overexpressing the ERBB2 gene.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 24(8):1055-9 [DOI] 10.1038/modpathol.2011.64. [PMID] 21499233.
2011
Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia.
Leukemia research. 35(5):579-84 [DOI] 10.1016/j.leukres.2010.10.020. [PMID] 21176961.
2010
Genomic, immunophenotypic, and NPM1/FLT3 mutational studies on 17 patients with normal karyotype acute myeloid leukemia (AML) followed by aberrant karyotype AML at relapse.
Cancer genetics and cytogenetics. 202(2):101-7 [DOI] 10.1016/j.cancergencyto.2010.07.117. [PMID] 20875872.
2010
Multiparameter flow cytometry for the diagnosis and monitoring of small GPI-deficient cellular populations.
Cytometry. Part B, Clinical cytometry. 78(5):348-56 [DOI] 10.1002/cyto.b.20519. [PMID] 20533383.
2009
Microsatellite instability in large cell neuroendocrine carcinoma of the female genital tract.
Histopathology. 55(5):621-5 [DOI] 10.1111/j.1365-2559.2009.03410.x. [PMID] 19912372.
2008
Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels.
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(5):1561-70 [DOI] 10.1158/1078-0432.CCR-07-1254. [PMID] 18316581.
2007
Increased frequency of uridine diphosphate glucuronosyltransferase 1A1 7/7 in patients experiencing severe irinotecan-induced toxicities.
Clinical colorectal cancer. 6(8):583-7 [PMID] 17681105.
View on: PubMed
2007
Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy.
Leukemia & lymphoma. 48(5):1053-6 [PMID] 17487757.
View on: PubMed
2006
Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 24(34):5343-9 [PMID] 17088571.
View on: PubMed
2005
Amplification of NOTCH1 and ABL1 gene loci is a frequent aberration in enteropathy-type T-cell lymphoma.
Virchows Archiv : an international journal of pathology. 446(4):416-20 [PMID] 15756589.
View on: PubMed
2005
CD117+ small cell lung cancer lacks the asp 816–>val point mutation in exon 17.
Histopathology. 47(5):517-22 [PMID] 16242000.
View on: PubMed
2003
Allelic losses on chromosome 6q25 in Hodgkin and Reed Sternberg cells.
Cancer research. 63(10):2606-9 [PMID] 12750286.
View on: PubMed
2003
Angioimmunoblastic T cell lymphoma is derived from mature T-helper cells with varying expression and loss of detectable CD4.
International journal of cancer. 103(1):12-20 [PMID] 12455048.
View on: PubMed
2003
Correlating genetic aberrations with World Health Organization-defined histology and stage across the spectrum of thymomas.
Cancer research. 63(13):3708-15 [PMID] 12839963.
View on: PubMed
2003
High frequency of genetic aberrations in enteropathy-type T-cell lymphoma.
Laboratory investigation; a journal of technical methods and pathology. 83(10):1509-16 [PMID] 14563952.
View on: PubMed
2003
Human ependymomas reveal frequent deletions on chromosomes 6 and 9.
Acta neuropathologica. 106(4):357-62 [PMID] 12898154.
View on: PubMed
2003
Semiquantitative and qualitative assessment of B-lymphocyte V H repertoire by a fluorescent multiplex PCR.
Journal of immunological methods. 276(1-2):121-7 [PMID] 12738364.
View on: PubMed
2002
A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency.
European journal of human genetics : EJHG. 10(9):499-504 [PMID] 12173025.
View on: PubMed
2002
Chromosomal gains at 9q characterize enteropathy-type T-cell lymphoma.
The American journal of pathology. 161(5):1635-45 [PMID] 12414511.
View on: PubMed
2002
Chromosome 6 suffers frequent and multiple aberrations in thymoma.
The American journal of pathology. 161(4):1507-13 [PMID] 12368223.
View on: PubMed
2002
Epstein-Barr virus-associated B-cell lymphoproliferative disorders in angloimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified.
American journal of clinical pathology. 117(3):368-79 [PMID] 11888076.
View on: PubMed
2002
Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways.
Blood. 99(1):3-9 [PMID] 11756145.
View on: PubMed
2002
Loss of heterozygosity on chromosome 22 in human ependymomas.
Acta neuropathologica. 103(4):415-20 [PMID] 11904762.
View on: PubMed
2002
Minimal residual low-grade gastric MALT-type lymphoma after eradication of Helicobacter pylori.
Lancet (London, England). 360(9332):547-8 [PMID] 12241663.
View on: PubMed
2002
Proficient mismatch repair protein expression in Hodgkin and Reed Sternberg cells.
International journal of cancer. 97(2):205-10 [PMID] 11774265.
View on: PubMed
2002
Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm.
The American journal of surgical pathology. 26(1):119-24 [PMID] 11756779.
View on: PubMed
2001
Diagnosis of microsatellite instability-positive colorectal cancer.
Expert review of molecular diagnostics. 1(1):71-80 [PMID] 11901802.
View on: PubMed
2001
Loss of Fas (CD95/APO-1) regulatory function is an important step in early MALT-type lymphoma development.
Laboratory investigation; a journal of technical methods and pathology. 81(7):977-86 [PMID] 11454987.
View on: PubMed
2001
Primary low-grade B cell non-Hodgkin’s lymphoma of MALT type simultaneously arising in the colon and in the lung: report of a case.
Diseases of the colon and rectum. 44(3):448-52 [PMID] 11289295.
View on: PubMed
2001
Thymic epithelial tumors can develop along two different pathogenetic pathways.
The American journal of pathology. 159(5):1853-60 [PMID] 11696445.
View on: PubMed
2000
Deletions in the 13q14 locus in adult lymphoblastic leukemia: rate of incidence and relevance.
Cancer. 88(6):1359-64 [PMID] 10717617.
View on: PubMed
2000
Genetic aberrations common in gastric high-grade large B-cell lymphoma.
Blood. 95(4):1180-7 [PMID] 10666188.
View on: PubMed
2000
Genetic imbalances in primary gastric diffuse large B-cell lymphomas: comparison of comparative genomic hybridization, microsatellite, and cytogenetic analysis.
Diagnostic molecular pathology : the American journal of surgical pathology, part B. 9(1):58-65 [PMID] 10718214.
View on: PubMed
2000
Histopathology and molecular pathology of synovial B-lymphocytes in rheumatoid arthritis.
Histology and histopathology. 15(3):791-8 [DOI] 10.14670/HH-15.791. [PMID] 10963123.
2000
The role of microsatellite instability in gastric low- and high-grade lymphoma development.
The American journal of pathology. 157(4):1129-36 [PMID] 11021817.
View on: PubMed
1999
ATM mutations in B-cell chronic lymphocytic leukemia.
Cancer research. 59(1):24-7 [PMID] 9892178.
View on: PubMed
1999
Infection with parapoxvirus induces CD30-positive cutaneous infiltrates in humans.
Journal of cutaneous pathology. 26(10):520-2 [PMID] 10599944.
View on: PubMed
1999
Molecular IgV(H) analysis demonstrates highly somatic mutated B cells in synovialitis of osteoarthritis: a degenerative disease is associated with a specific, not locally generated immune response.
Laboratory investigation; a journal of technical methods and pathology. 79(11):1377-84 [PMID] 10576208.
View on: PubMed
1999
The prognostic significance of 13q14 deletions in chronic lymphocytic leukemia.
Leukemia research. 23(9):795-801 [PMID] 10475618.
View on: PubMed
1999
Use of peripheral blood blasts vs bone marrow blasts for diagnosis of acute leukemia.
American journal of clinical pathology. 111(6):733-40 [PMID] 10361507.
View on: PubMed
1998
Deficiency of the ATM protein expression defines an aggressive subgroup of B-cell chronic lymphocytic leukemia.
Cancer research. 58(20):4552-7 [PMID] 9788599.
View on: PubMed
1996
The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif.
Molecular and cellular biology. 16(12):7173-81 [PMID] 8943373.
View on: PubMed
1996
Transcriptional repression and growth suppression by the p107 pocket protein.
Molecular and cellular biology. 16(7):3606-14 [PMID] 8668177.
View on: PubMed

Grants

Jul 2020 ACTIVE
White House Study: Evaluate COVID-19 Detection Technology
Role: Co-Investigator
Funding: ASST SEC FOR PREPAREDNESS AND RESPONSE
Jul 2020 ACTIVE
Precision antiplatelet therapy after percutaneous coronary intervention
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jun 2020 ACTIVE
RADIANT Core Laboratory Proposal 2020-21
Role: Co-Investigator
Funding: UNIV OF CHICAGO via NATL INST OF HLTH NIDDK
Aug 2019 ACTIVE
BARDA DRIVe HostDx Sepsis UF (Clinical Validation and Implementation of HostDX Sepsis on NanoString)
Role: Co-Investigator
Funding: INFLAMMATIX via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Sep 2018 ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Jun 2013 – Sep 2018
Genomic Medicine Implementation: The Personalized Medicine Program
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI

Education

Fellowship – Hematophathy
1997 · Anderson Cancer Center
Residency – Pathology
1995 · Washington University
Medical Degree
1982 · Vienna University School of Medicine, Vienna, Austria

Teaching Profile

Courses Taught
2019
PHA6136 Clinical Applications of Precision Medicine: Oncology
2021
PHA6935 Selected Topics in Pharmacy

Contact Details

Phones:
Business:
(352) 265-9900
Emails: