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Foundations in Precision Medicine Courses
Genomic technologies are emerging technologies used to manipulate and analyze genomic information. The course content will focus on current developments and emerging trends in genomic testing, clinical and research applications of emerging genomic tests, role of computing and data science, and applications of bioinformatics in genomics. The objective of this course is to help you understand how data from current and emerging genomic tests are generated, analyzed, stored, and potentially used to inform research or clinical decision-making strategies.
Provides foundational knowledge on human genetics/genomics, including pedigree analysis, non-Mendelian genetics, cytogenetics, polymorphism analysis, physical mapping and the human genome, mutation analysis and pathogenesis, genomic imprinting, viral and non-viral gene therapy.
Reviews clinically important principles of genetic epidemiology, including population genetics, familial aggregation and heritability analysis, TagSNPs and haplotype blocks, population-based studies, GWAS and issues related to genetic association studies and epigenetics.
Clinical Application Courses
Reviews knowledge and applications of precision medicine diagnosis and treatment considerations of concepts in monogenic diseases and complex diseases. Important concepts include susceptibility genomics, diagnostic approaches, laboratory testing and treatment considerations for genomic medicine. Diseases include cystic fibrosis, monogenic diabetes, Marfan syndrome, Huntington’s disease, as well as cardiovascular, metabolic, neurologic, mental health disorders and addiction and others.
Reviews knowledge and clinical applications of precision medicine approaches and technologies in diagnosing or treating cancer, including the genetics of cancer, targeted cancer treatments, somatic testing, current and future research and clinical trends and other information.
Additional Course Electives
Utilizes the framework of pharmacogenomics to lay the foundation for understanding other types of omic and pharmaco-omic study designs and analyses. The course will use a combination of lectures, discussions of assigned literature, small group discussions, projects and student-led presentations. This courses is offered in person at UF College of Pharmacy Gainesville campus only.
This course will provide an overview of the use of pharmacogenomic data to inform clinical and therapeutic decision making for gene-drug pairs across a range of conditions.
Explore ways to implement use of pharmacogenetic tests in patient care. The course will address barriers to clinical implementation of pharmacogenetic tests by referencing appropriate guidelines and evidence-based and peer-review recourses.
This is an introduction to biomedical ethics primarily as applied to pharmaceutical and medical device products. Subject areas include the provider-patient relationship, clinical research ethics, distribution of scarce resources, ethics and industry, and beginning and end of life issues. Topics of special interest are tissue engineering and stem cells, human cloning, xenotransplantation, defining diseases, genetic testing, and genomically customized medications.
This course provides a through introduction to the way modern pharmaceuticals (drugs) are discovered, developed, regulated, and marketed. It is intended to give the student an overview of how the pharmaceutical industry operates and the various functional roles of the people involved.
Requirements and strategies for patient education in precision medicine are rapidly changing due to emerging technologies, new types of testing, and increasing availability to generalist providers. Content will focus on emerging issues in patient education and communication in precision medicine. Topics include review of traditional and emerging models of patient education in genetic testing, workforce educational needs and strategies, implications and communication strategies for areas of uncertainty (e.g., variants of unknown significance, test reimbursement), essential topics and strategies to consider for patient diversity and health disparities, and legal and ethical issues in patient education and communication in precision medicine.
The late 20th century rapid development of new genetic technologies that enabled the mapping and sequencing in the Human Genome Project, as well as non-human life forms has had a profound impact on human society and our self-understanding. This technology has sometimes proceeded at a pace that threatens to outstrip our collective wisdom as to how it should be assimilated and regulated, both for individuals and for organizational entities from reproductive clinics and labs to national research institutions and entire societies. This course will introduce participants to these issues and explore proposed solutions as well as, as yet unsolved, problems. The course will focus primarily on human medical applications, but will also include some topics in social contexts wider than an exclusively medical context.
Special Topics (Master’s Degree)
This required course must be taken in in the final semester, and students take a final comprehensive exam using ProctorU. Students should plan to take one elective in addition to this required course to meet the University of Florida graduation requirements.
|Course #||Course Title||Credits||Spring||Summer||Fall|
|PHA 6136||Clinical Applications of Precision Medicine: Oncology||3||x|
|PHA 6613||Clinical Applications of Precision Medicine: Precision Health||3||x|
|PHA 6935||Ethics in Drug Production, Distribution, and Use||3||x||x|
|PHA 6935||Ethics in Genetics||3||x|
|PHA 6935||Principles of Pharmacogenomics||3||x||x||x|
|PHA 6935||Applied Statistics for Data Analysis||3||x||x||x|
|PHA 6936||Pharmaceutical Research and Development: Foundations and Impact on Precision Medicine||3||x||x||x|
|PHA 6935||Case Studies in Clinical Pharmacogenomics||2||x||x|
|PHA 6935||Clinical Pharmacogenomics Implementation||2||x||x|
|PHA 6134||Foundations of Precision Medicine: Genomic Technologies||1||x||x||x|
|GMS 6224||Foundations of Precision Medicine: Medical Molecular Genetics||1||x||x||x|
|PHA 6598||Foundations of Precision Medicine: Genetic Epidemiology||1||x||x||x|
|PHA 6746||Patient Education and Communication in the Era of Precision Medicine||1||x||x|
|PHA 6936||Special Topics in Precision Medicine (exam ProctorU)||1||x||x||x|