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Foundations in Precision Medicine Courses
Overview of current developments and trends in emerging genomic technologies, including data science technology, genetic and genomic testing and reporting, big data, bioinformatics, clinical decision support and other genetic applications supported by emerging technologies.
Provides foundational knowledge on human genetics/genomics, including pedigree analysis, non-Mendelian genetics, cytogenetics, polymorphism analysis, physical mapping and the human genome, mutation analysis and pathogenesis, genomic imprinting, viral and non-viral gene therapy.
Reviews clinically important principles of genetic epidemiology, including population genetics, familial aggregation and heritability analysis, TagSNPs and haplotype blocks, population-based studies, GWAS and issues related to genetic association studies and epigenetics.
Consists of content presented at the UF Precision Medicine Conference. The seminar brings together precision medicine experts to provide the latest information and implications of discovery, trends, technologies, and clinical applications of genomic/genetic data. Although the graduate course and conference have separate components, students are welcome to attend the conference live. The graduate course included though provoking assignments and discussions, and a capstone project that furthers the discussions presented at the live conference.
Clinical Application Courses
Reviews knowledge and applications of precision medicine diagnosis and treatment considerations of concepts in monogenic diseases and complex diseases. Important concepts include susceptibility genomics, diagnostic approaches, laboratory testing and treatment considerations for genomic medicine. Diseases include cystic fibrosis, monogenic diabetes, Marfan syndrome, Huntington’s disease, as well as cardiovascular, metabolic, neurologic, mental health disorders and addiction and others.
Reviews knowledge and clinical applications of precision medicine approaches and technologies in diagnosing or treating cancer, including the genetics of cancer, targeted cancer treatments, somatic testing, current and future research and clinical trends and other information.
Includes knowledge and clinical applications of pharmacogenomics in precision medicine, including its contribution to variability in drug metabolism, use of pharmacogenomics to identify patients at risk for adverse drug reactions and clinical use of pharmacogenomic data in drug therapy for multiple therapeutic areas, including cardiovascular.
Additional Course Electives
Introduces biostatistical concepts and methods used in pharmacy and medical literature. The overall goal of the course is for students to develop the ability to critically evaluate the statistical tests and results of relevant literature to identify findings that have implications for their practice. This course is offered in conjunction with UF College of Pharmacy Departments of Pharmaceutical Outcomes and/or Medicinal Chemistry. Tuition rate and course requirements may differ.
Utilizes the framework of pharmacogenomics to lay the foundation for understanding other types of omic and pharmaco-omic study designs and analyses. The course will use a combination of lectures, discussions of assigned literature, small group discussions, projects and student-led presentations. This courses is offered in person at UF College of Pharmacy Gainesville campus only.
This course will provide an overview of the use of pharmacogenomic data to inform clinical and therapeutic decision making for gene-drug pairs across a range of conditions.
Explore ways to implement use of pharmacogenetic tests in patient care. The course will address barriers to clinical implementation of pharmacogenetic tests by referencing appropriate guidelines and evidence-based and peer-review recourses.
This is an introduction to biomedical ethics primarily as applied to pharmaceutical and medical device products. Subject areas include the provider-patient relationship, clinical research ethics, distribution of scarce resources, ethics and industry, and beginning and end of life issues. Topics of special interest are tissue engineering and stem cells, human cloning, xenotransplantation, defining diseases, genetic testing, and genomically customized medications.
This 2-credit course involves the completion of a term paper on a relevant topic of precision medicine. Students will research scientific literature available to them online, through the UF e-journals, and other relevant sources. Students will prepare a fully referenced term paper in no less than 5000 words on a precision medicine-related subject approved by the course instructor.
Further develops the knowledge and skills necessary to appraise peer-reviewed pharmacogenomic literature. This course will provide opportunities to critically evaluate literature focused on both discovery and implementation of gene-drug pairs, become informed about research developments in pharmacogenomics, and further develop presentation skills in a seminar format.
Special Topics (Master’s Degree)
This required course must be taken in in the final semester, and students take a final comprehensive exam using ProctorU. Students should plan to take one elective in addition to this required course to meet the University of Florida graduation requirements.
|Course #||Course Title||Credits||Spring||Summer||Fall|
|PHA 6935||Foundations:Principles of Pharmacogenomics and Genomic Technologies||3||x||x|
|GMS 6224||Foundations: Medical Molecular Genetics||1||x||x|
|PHA 6935||Precision Medicine Seminar||2||x||x|
|PHA 6598||Foundations: Genetic Epidemiology||1||x||x|
|PHA 6613||Clinical Applications: Precision Health||3||x|
|PHA 6935||Clinical Applications: Oncology||3||x|
|PHA 6135||Clinical Applications: Pharmacogenomics||2||x|
|PHA 6449||Pharmacogenomics and Genomics Data Analysis||3||x|
|PHA 6935||Case Studies in Clinical Pharmacogenomics||2||x||x|
|PHA 6935||Clinical Pharmacogenomics Implementation||2||x||x|
|PHA 6936||Literature Survey in Personalized Medicine||2||x||x||x|
|PHA 6277||Ethics in Drug Production, Distribution, and Use||3||x|
|PHA 6935||Pharmacogenomics Literature Assessment||1||x||x||x|
|PHA 6935||Applied Statistics for Data Analysis||3||x||x||x|
|PHA 6936||Special Topics in Personalized Medicine (exam ProctorU)||1||x||x||x|